This framework, developed by TDR and the Global Health Network, lists the competencies that should be demonstrated by the research team as a whole to carry out a successful clinical study. This flexible framework can be applied to any clinical research study, regardless of the size of the team, place, disease focus and type of research. Together with its supporting tools, the framework can be used to: plan staffing requirements for a study, carry out appraisals of staff, and create educational curricula for research staff.