Griffithsin and Carrageenan Fast-Dissolving Vaginal Insert
- User: Female
- Hormonal: Non-Hormonal
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Delivery type:
- Vaginal - Other
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Intended Duration:
- Short-Acting
- Pericoital
- Development Stage: Pre-Clinical
- Developer(s)/researcher(s): Population Council
Details
- API: Griffithsin + Carrageenan
- Target: GP120, Other Targets Not Yet Determined
-
Mechanism of Action:
- Inhibition of Sperm Motility
- Inhibition of Sperm Capacitation
- Inactive Materials: Not Yet Determined
- Regimen: On Demand
- MPT: Potential MPT
- Promising Attributes: Fast dissolving inserts are inexpensive and portable, and are supported by user acceptability data. An on-demand option that provides contraceptive protection and reduces risk of HIV or HPV transmission may be appealing.
Product Status
Developer Confirms Product is Inactive
History
See linked literature below for information on safety and biocompatibility
Griffithsin, an anti-HIV Lectin, and carrageenan, a polysaccharide known to act against HPV, may also provide a contraceptive benefit. Population Council pursued the development of a fast-dissolving vaginal insert containing these API.