NES Implant
Nestorone (NES) Single Rod Implant
- User: Female
- Hormonal: Hormonal
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Delivery type:
- Subdermal
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Intended Duration:
- Long-Acting
- Development Stage: Phase II
- Developer(s)/researcher(s): Population Council
Details
- API: Nestorone
- Target: Progesterone Receptor
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Mechanism of Action:
- Ovulation Inhibition
- Cervical Mucus Changes
- Endometrial Changes
- Inactive Materials: Silastic
- Regimen: 1 Insertion/2 Years
- MPT: Not Potential MPT
Product Status
No development after early 2000s
History
Phase IIb study stopped due to higher than expected failure rate in women who were not breastfeeding. Phase II in breastfeeding women successful both in efficacy and safety in mothers and infants.