Oleanolic Acid
- User: Male
- Hormonal: Non-Hormonal
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Delivery type:
- Not Yet Determined
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Intended Duration:
- Short-Acting
- Development Stage: Discovery & Early Development
- Developer(s)/researcher(s): South African Medical Research Council, University of Western Cape, University of Missouri
Details
- API: Oleanolic Acid
- Target: Not Yet Determined
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Mechanism of Action:
- Not Yet Determined
- Inactive Materials: Not Yet Determined
- Regimen: Not Yet Determined
- MPT: Not Potential MPT
- Promising Attributes: OA may be viable for inclusion in a reversible male contraceptive product. Researchers have suggested that such a product may have minimal side effects, due to OA's high biocompatibility and favorable toxicology profile.
Product Status
While the research groups at the University of the Western Cape and the University of Missouri have not published results on OA and male contraception since 2019, the project is still featured on the lead researcher's academic profile, indicating potential ongoing interest.
History
Oleanolic acid, a naturally occurring triterpenoid found in a wide range of plants, has been evaluated for its anti-fertility properties since at least 1988. In vivo research has indicated that the triterpenoid significantly impacts sperm motility, and 2019 mouse studies found that OA could cause reversable infertility through its impact on the germinal epithelium.