New Clinical Trial Shows Estetrol/Drospirenone Significantly Eases Menstrual Symptoms

Contraceptive pill pack on a pink background RHSC/Unsplash
News POSTED Apr 17, 2025 By CTI Exchange Staff

A recent publication in Contraception by Bouchard et al. has revealed promising results from a phase 3 clinical trial conducted in the United States and Canada. The study evaluated the effects of estetrol combined with drospirenone on self-reported physical and emotional premenstrual and menstrual symptoms. Participants reported significant improvements in symptoms such as menstrual pain, mood swings, and other menstrual complaints.

Co-author, Dr. Mitchell Creinin from the University of California Davis Health recently discussed these findings with Celeste Krewson of Contemporary OBGYN, emphasizing the substantial benefits of estetrol/drospirenone for both new and switching contraceptive users. The study showed that this novel oral contraceptive significantly reduces menstrual distress, offering a valuable option for individuals seeking relief from menstrual symptoms.